2023年 01期

不同价态钒氧化物的细胞毒性评估

Cytotoxicity Evaluation of Vanadium Oxides with Different Valences


摘要(Abstract):

为了对单斜晶型M相二氧化钒粉体氧化过程中可能形成的多种价态钒氧化物的细胞毒性进行评估,选取并制备价态依次增加的二氧化钒、十三氧化六钒、一水合七氧化三钒和五氧化二钒4种钒氧化物,通过细胞形态观察和细胞活性测定2种方式评估不同价态及质量浓度为1~500 mg/L的钒氧化物对小鼠成纤维细胞L929的细胞毒性。结果表明,处理24 h后的L929细胞的细胞活性在不同价态钒氧化物中由弱到强的顺序为五氧化二钒、一水合七氧化三钒、十三氧化六钒、二氧化钒,说明钒氧化物的细胞毒性随着价态的增加而增强。

关键词(KeyWords): 钒氧化物;细胞毒性;细胞形态;细胞活力

基金项目(Foundation): 国家自然科学基金项目(61771327,U20A20212,U1930123)

作者(Author):唐露,路学光,毛振娅,施奇武,余修贤,万城渝,彭穗,刘波,黄婉霞

DOI: 10.13349/j.cnki.jdxbn.20221020.001

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