参考文献(References)：
[1] MICHALOGLOU C,VREDEVELD L C W,SOENGAS M S,et al.BRAFE600-associated senescence-like cell cycle arrest of human naevi[J].Nature,2005,436(7051):720-724.
[2] COLLADO M,GIL J,EFEYAN A,et al.Tumour biology:senescence in premalignant tumours[J].Nature,2005,436(7051):642.
[3] CHEN Z B,TROTMAN L C,SHAFFER D,et al.Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis[J].Nature,2005,436(7051):725-730.
[4] BRAIG M,LEE S,LODDENKEMPER C,et al.Oncogene-induced senescence as an initial barrier in lymphoma development[J].Nature,2005,436(7051):660-665.
[5] SARKISIAN C J,KEISTER B A,STAIRS D B,et al.Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis[J].Nature Cell Biology,2007,9:493-505.
[6] DANKORT D,FILENOVA E,COLLADO M,et al.A new mouse model to explore the initiation,progression,and therapy of BRAFV600E-induced lung tumors[J].Genes & Development,2007,21:379-384.
[7] BENATAR T,YANG W Y,AMEMIYA Y,et al.IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways[J].Breast Cancer Research and Treatment,2012,133:563-573.
[8] LANDBERG G,?STLUND H,NIELSEN N H,et al.Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein,cyclin E overexpression and increased proliferation in estrogen receptor negative tumors[J].Oncogene,2001,20:3497-3505.
[9] BOJKO A,CZARNECKA-HEROK J,CHARZYNSKA A,et al.Diversity of the senescence phenotype of cancer cells treated with chemotherapeutic agents[J].Cells,2019,8(12):1501.
[10] ROBERSON R S,KUSSICK S J,VALLIERES E,et al.Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers[J].Cancer Research,2005,65(7):2795-2803.
[11] SANOFF H K,DEAL A M,KRISHNAMURTHY J,et al.Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer[J].Journal of the National Cancer Institute,2014,106(4):dju057.
[12] SCHWARZE S R,FU V X,DESOTELLE J A,et al.The identification of senescence-specific genes during the induction of senescence in prostate cancer cells[J].Neoplasia,2005,7(9):816-823.
[13] EWALD J A,PETERS N,DESOTELLE J A,et al.A high-throughput method to identify novel senescence-inducing compounds[J].Journal of Biomolecular Screening,2009,14(7):853-858.
[14] COTTART C-H,NIVET-ANTOINE V,LAGUILLIER-MORIZOT C,et al.Resveratrol bioavailability and toxicity in humans[J].Molecular Nutrition & Food Research,2010,54(1):7-16.
[15] CHAI R F,FU H L,ZHENG Z D,et al.Resveratrol inhibits proliferation and migration through SIRT1 mediated post translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells[J].Molecular Medicine Reports,2017,16(6):8037-8044.
[16] TIAN X X,ZHANG S Z,ZHANG Q,et al.Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma[J].The Journal of Nutritional Biochemistry,2020,85:108489.
[17] AL-ABD A M,MAHMOUD A M,EL-SHERBINY G A,et al.Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro[J].Cell Proliferation,2011,44:591-601.
[18] MONDAL A,BENNETT L L.Resveratrol enhances the efficacy of sorafenib mediated apoptosis in human breast cancer MCF7 cells through ROS,cell cycle inhibition,caspase 3 and PARP cleavage[J].Biomedicine & Pharmacotherapy,2016,84:1906-1914.
[19] SIKORA E,ARENDT T,BENNETT M,et al.Impact of cellular senescence signature on ageing research[J].Ageing Research Reviews,2011,10(1):146-152.
[20] LEE S,LEE J S.Cellular senescence:a promising strategy for cancer therapy[J].BMB Reports,2019,52(1):35-41.
[21] OTT C,JUNG T,GRUNE T,et al.SIPS as a model to study age-related changes in proteolysis and aggregate formation[J].Mechanisms of Ageing and Development,2018,170:72-81.
[22] NARITA M,NU?EZ S,HEARD E,et al.Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence[J].Cell,2003,113(6):703-716.
[23] ARIANNA C,ANDREA A.Aging tumour cells to cure cancer:“pro-senescence” therapy for cancer[J].Swiss Medical Weekly,2017,147:w14367.
[24] KURZ D J,DECARY S,HONG Y,et al.Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells[J].Journal of Cell Science,2000,113 (20):3613-3622.
[25] BAKER D J,WIJSHAKE T,TCHKONIA T,et al.Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders[J].Nature,2011,479(7372):232-236.
[26] WANG E.Senescent human fibroblasts resist programmed cell death,and failure to suppress bcl2 is involved[J].Cancer Research,1995,55(11):2284-2292.
[27] SELUANOV A,GORBUNOVA V,FALCOVITZ A,et al.Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53[J].Molecular and Cellular Biology,2001,21(5):1552-1564.
[28] KANG T W,YEVSA T,WOLLER N,et al.Senescence surveillance of pre-malignant hepatocytes limits liver cancer development[J].Nature,2011,479(7374):547-551.
[29] CHEN Q M,BARTHOLOMEW J C,CAMPISI J,et al.Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts:p53 and Rb control G1 arrest but not cell replication[J].The Biochemical Journal,1998,332(1):43-50.
[30] TSAI I C,PAN Z C,CHENG H P,et al.Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence[J].Journal of Molecular and Cellular Cardiology,2016,98:18-27.
[31] LIANG Q X,LIN Y H,ZHANG C H,et al.Resveratrol increases resistance of mouse oocytes to postovulatory aging in vivo[J].Aging,2018,10(7):1586-1596.
[32] 张贤益.白藜芦醇对D-gal致衰老小鼠的保护作用及机制探究[D].南昌：南昌大学，2019.
[33] HEISS E H,SCHILDER Y D C,DIRSCH V M.Chronic treatment with resveratrol induces redox stress-and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells[J].The Journal of Biological Chemistry,2007,282(37):26759-26766.
[34] LUO H M,YANG A M,SCHULTE B A,et al.Resveratrol induces premature senescence in lung cancer cells via ROS-mediated DNA damage[J].PLoS One,2013,8(3):e60065.
[35] LI B X,HOU D,GUO H Y,et al.Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells[J].Scientific Reports,2017,7(1):208.
[36] LUO H M,WANG L,SCHULTE B A,et al.Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells[J].International Journal of Oncology,2013,43(6):1999-2006.
[37] JI S H,ZHENG Z D,LIU S,et al.Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells[J].Experimental Cell Research,2018,370(2):292-302.
[38] LIU T T,QI H,MA L,et al.Resveratrol attenuates oxidative stress and extends life span in the annual fish Nothobranchius guentheri[J].Rejuvenation Research,2015,18(3):225-233.
[39] LIU T T,MA L,ZHENG Z D,et al.Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri[J].Oncotarget,2017,8(33):55422-55434.
[40] SERRANO M,LIN A W,McCURRACH M E,et al.Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a[J].Cell,1997,88(5):593-602.
[41] COURTOIS-COX S,JONES S L,CICHOWSKI K.Many roads lead to oncogene-induced senescence[J].Oncogene,2008,27:2801-2809.
[42] ACOSTA J C,O'LOGHLEN A,BANITO A,et al.Chemokine signaling via the CXCR2 receptor reinforces senescence[J].Cell,2008,133(6):1006-1018.
[43] KUILMAN T,MICHALOGLOU C,VREDEVELD L C W,et al.Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network[J].Cell,2008,133(6):1019-1031.
[44] GUAN M,ZHOU X L,SOULITZIS N,et al.Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer:potential clinical applications[J].Clinical Cancer Research,2006,12(5):1412-1419.
[45] CASTRO M,GRAU L,PUERTA P,et al.Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer[J].Journal of Translational Medicine,2010,8:86.
[46] YANG Y T,CUI J J,XUE F,et al.Resveratrol represses Pokemon expression in human glioma cells[J].Molecular Neurobiology,2016,53:1266-1278.
[47] D’ADDA D FAGAGNA F.Living on a break:cellular senescence as a DNA-damage response[J].Nature Reviews Cancer,2008,8:512-522.
[48] PRIEUR A,PEEPER D S.Cellular senescence in vivo:a barrier to tumorigenesis[J].Current Opinion in Cell Biology,2008,20(2):150-155.
[49] KUO L J,YANG L X.Gamma-H2AX:a novel biomarker for DNA double-strand breaks[J].In Vivo,2008,22(3):305-309.
[50] HUEN M S Y,CHEN J J.ATM creates a veil of transcriptional silence[J].Cell,2010,141(6):924-926.
[51] ZAJKOWICZ A,KRZE,et al.Nutlin-3a,an MDM2 antagonist and p53 activator,helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol[J].Molecular Biology Reports,2013,40:5013-5026.
[52] FANG Y J,DeMARCO V G,NICHOLL M B.Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis[J].Cancer Science,2012,103(6):1090-1098.
[53] WEN F C,CHANG T W,TSENG Y L,et al.hRAD9 functions as a tumor suppressor by inducing p21-dependent senescence and suppressing epithelial-mesenchymal transition through inhibition of slug transcription[J].Carcinogenesis,2014,35(7):1481-1490.
[54] CHEN K Y,CHEN C C,CHANG Y C,et al.Resveratrol induced premature senescence and inhibited epithelial-mesenchymal transition of cancer cells via induction of tumor suppressor Rad9[J].PLoS One,2019,14(7):e0219317.
[55] LEON-GALICIA I,DIAZ-CHAVEZ J,ALBINO-SANCHEZ M E,et al.Resveratrol decreases Rad51 expression and sensitizes cisplatin resistant MCF-7 breast cancer cells[J].Oncology Reports,2018,39(6):3025-3033.
[56] RUSIN M,ZAJKOWICZ A,BUTKIEWICZ D.Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1[J].Mechanisms of Ageing and Development,2009,130(8):528-537.
[57] 曾鸣，郭莲娣，王鑫，等.组蛋白H2B单泛素化参与DNA损伤修复的调控机制[J].中国科学：生命科学，2014,44(7):702-710.
[58] GAO Z,XU M S,BARNETT T L,et al.Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells[J].Biochemical and Biophysical Research Communications,2011,407(2):271-276.
[59] ROBERT C,RASSOOL F V.HDAC inhibitors:roles of DNA damage and repair[J].Advances in Cancer Research,2012,116:87-129.
[60] HEHLGANS S,STORCH K,LANGE I,et al.The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy[J].Radiotherapy and Oncology,2013,109(1):126-132.
[61] VARGAS J E,FILIPPI-CHIELA E C,SUHRE T,et al.Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells[J].Biochemistry and Cell Biology,2014,92(4):297-304.
[62] BACK J H,ZHU Y C,CALABRO A,et al.Resveratrol-mediated downregulation of Rictor attenuates autophagic process and suppresses UV-induced skin carcinogenesis[J].Photochemistry and Photobiology,2012,88(5):1165-1172.
[63] LU J J,ZHANG L P,CHEN X,et al.SIRT1 counteracted the activation of STAT3 and NF-κB to repress the gastric cancer growth[J].International Journal of Clinical and Experimental Medicine,2014,7(12):5050-5058.
[64] YANG Q,WANG B,ZANG W,et al.Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a Sirt1-dependent manner[J].PLoS One,2013,8(11):e70627.
