参考文献(References)：
[1] CAI C,HUA Y,LI H P,et al.Hydrothermal treatment of erythromycin fermentation residue:harmless performance and bioresource properties[J].Resources Conservation and Recycling,2020,161:104952.
[2] MARTíNEZ J L,COQUE T M,BAQUERO F.What is a resistance gene?:ranking risk in resistomes[J].Nature Reviews Microbiology,2015,13(2):116.
[3] QIAO M,YING G G,SINGER A C,et al.Review of antibiotic resistance in China and its environment[J].Environment International,2018,110:160.
[4] PEHRSSON E C,TSUKAYAMA P,PATEL S,et al.Interconnected microbiomes and resistomes in low-income human habitats[J].Nature,2016,533(7602):212.
[5] 齐亚兵，张思敬，孟晓荣，等.抗生素废水处理技术现状及研究进展[J].应用化工，2021,50(9):2587.
[6] TIWARI B,SELLAMUTHU B,OUARDA Y,et al.Review on fate and mechanism of removal of pharmaceutical pollutants from wastewater using biological approach[J].Bioresource Technology,2017,224:1.
[7] OBEROI A S,JIA Y Y,ZHANG H Q,et al.Insights into the fate and removal of antibiotics in engineered biological treatment systems:a critical review[J].Environmental Science & Technology,2019,53(13):7234.
[8] MANGALGIRI K P,IBITOYE T,BLANEY L.Molar absorption coefficients and acid dissociation constants for fluoroquinolone,sulfonamide,and tetracycline antibiotics of environmental concern[J].Science of the Total Environment,2022,835:155508.
[9] YANG S F,LIN C F,WU C J,et al.Fate of sulfonamide anti-biotics in contact with activated sludge-sorption and biodegradation[J].Water Research,2012,46(4):1304.
[10] SONG X C,LIU D F,ZHANG G W,et al.Adsorption mech-anisms and the effect of oxytetracycline on activated sludge[J].Bioresource Technology,2014,151:428.
[11] ROGERS H R.Sources,behaviour and fate of organic contaminants during sewage treatment and in sewage sludges[J].Science of the Total Environment,1996,185(1/2/3):3.
[12] LUO Y L,GUO W S,NGO H H,et al.A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment[J].Science of the Total Environment,2014,473-474:619.
[13] TRAN N H,CHEN H J,REINHARD M,et al.Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes[J].Water Research,2016,104:461.
[14] MüLLER E,SCHUSSLER W,HORN H,et al.Aerobic biodegradation of the sulfonamide antibiotic sulfamethoxazole by activated sludge applied as co-substrate and sole carbon and nitrogen source[J].Chemosphere,2013,92(8):969.
[15] WUNDER D B,BOSSCHER V A,COK R C,et al.Sorption of antibiotics to biofilm[J].Water Research,2011,45(6):2270.
[16] ZHANG H Q,JIA Y Y,KHANAL S K,et al.Understanding the role of extracellular polymeric substances on ciprofloxacin adsorption in aerobic sludge,anaerobic sludge,and sulfate-reducing bacteria sludge systems[J].Environmental Science & Technology,2018,52(11):6476.
[17] LI S J,PENG L,YANG C G,et al.Cometabolic biodegradation of antibiotics by ammonia oxidizing microorganisms during wastewater treatment processes[J].Journal of Environmental Management,2022,305:114336.
[18] WANG X,ZHANG Z H,YUAN K K,et al.Cytochrome P450-mediated co-metabolism of fluoroquinolones by Haematococcus lacustris for simultaneously promoting astaxanthin and lipid accumulation[J].Chemical Engineering Journal,2023:465.
[19] JIANG B C,LI A,CUI D,et al.Biodegradation and metabolic pathway of sulfamethoxazole by Pseudomonas psychrophila HA-4,a newly isolated cold-adapted sulfamethoxazole-degrading bacter-ium[J].Applied Microbiology and Biotechnology,2014,98(10):4671.
[20] FISCHER K,MAJEWSKY M.Co-metabolic degradation of organic wastewater micropollutants by activated sludge and sludge-inherent microorganisms[J].Applied Microbiology and Biotechnology,2014,98(15):6583.
[21] GUO N,LIU M M,YANG Z H,et al.The synergistic mech-anism of β-lactam antibiotic removal between ammonia-oxidizing microorganisms and heterotrophs[J].Environmental Research,2023,216(Pt 1):114419.
[22] COPETE-PERTUZ L S,PLáCIDO J,SERNA-GALVIS E A,et al.Elimination of isoxazolyl-penicillins antibiotics in waters by the ligninolytic native colombian strain Leptosphaerulina sp.considerations on biodegradation process and antimicrobial activity removal[J].Science of the Total Environment,2018,630:1199.
[23] ZHANG L,GUO R X,LI H T,et al.Mechanism analysis for the process-dependent driven mode of NaHCO3 in algal antibiotic removal:efficiency,degradation pathway and metabolic response[J].Journal of Hazardous Materials,2020,394:122531.
[24] DONG K,WANG W B,LI M,et al.Degradation of sulfonamide antibiotics in the rhizosphere of two dominant plants in Huixian karst wetland,Guangxi,China[J].Water Reuse,2023,13(1):25.
[25] LIU M R,NI H Y H,YANG L,et al.Pretreatment of swine manure containing β-lactam antibiotics with whole-cell biocatalyst to improve biogas production[J].Journal of Cleaner Production,2019,240.
[26] CHATURVEDI P,GIRI B S,SHUKLA P,et al.Recent advancement in remediation of synthetic organic antibiotics from environmental matrices:challenges and perspective[J].Bioresource Technology,2021,319:124161.
[27] HUANG A R,YAN M T,LIN J J,et al.A Review of processes for removing antibiotics from breeding wastewater[J].International Journal of Environmental Research and Public Health,2021,18(9).
[28] SHAO S C,HU Y Y,CHENG C,et al.Simultaneous degradation of tetracycline and denitrification by a novel bacterium,Klebsiella sp.SQY5[J].Chemosphere,2018,209:35.
[29] ALEXANDRINO D A M,MUCHA A P,ALMEIDA C M R,et al.Biodegradation of the veterinary antibiotics enrofloxacin and ceftiofur and associated microbial community dynamics[J].Science of the Total Environment,2017,581-582:359.
[30] YANG C W,LIU C,CHANG B V.Biodegradation of amoxicillin,tetracyclines and sulfonamides in wastewater sludge[J].Water,2020,12(8).
[31] FENG N X,YU J,XIANG L,et al.Co-metabolic degradation of the antibiotic ciprofloxacin by the enriched bacterial consortium XG and its bacterial community composition[J].Science of the Total Environment,2019,665:41.
[32] MANASFI R,CHIRON S,MONTEMURRO N,et al.Biodegradation of fluoroquinolone antibiotics and the climbazole fungicide by Trichoderma species[J].Environmental Science and Pollution Research 2020,27(18):23331.
[33] PANJA S,SARKAR D,DATTA R.Removal of antibiotics and nutrients by vetiver grass (Chrysopogon zizanioides) from secondary wastewater effluent[J].International Journal of Phytoremediation,2020,22(7):764.
[34] PANJA S,SARKAR D,LI K,et al.Uptake and transformation of ciprofloxacin by vetiver grass (Chrysopogon zizanioides)[J].International Biodeterioration & Biodegradation,2019,142:200.
[35] YIN F,DONG H,ZHANG W,et al.Removal of combined antibiotic (florfenicol,tylosin and tilmicosin) during anaerobic digestion and their relative effect[J].Renewable Energy,2019,139:895.
[36] HOU J,CHEN Z,GAO J,et al.Simultaneous removal of antibiotics and antibiotic resistance genes from pharmaceutical wastewater using the combinations of up-flow anaerobic sludge bed,anoxic-oxic tank,and advanced oxidation technologies[J].Water Research,2019,159:511.
[37] COSKUN T,KABUK H A,VARINCA K B,et al.Antibiotic fermentation broth treatment by a pilot upflow anaerobic sludge bed reactor and kinetic modeling[J].Bioresource Technology,2012,121:31.
[38] ZHANG J,CHEN G,ZHANG Q,et al.Adaption strategy of up-flow anaerobic sludge blanket reactor on tetracycline stress during tetracycline antibiotic wastewater treatment[J].Environmental Engineering Research,2021,27(3):200597.
[39] MENG L W,WANG J C,LI X K,et al.Microbial community and molecular ecological network in the EGSB reactor treating antibiotic wastewater:response to environmental factors[J].Ecotoxicology and Environmental Safety,2021,208:111669.
[40] CHEN H Y,LIU G G,WANG K,et al.Characteristics of microbial community in EGSB system treating with oxytetracycline production wastewater[J].Journal of Environmental Management,2021,295:113055.
[41] ZHANG Z H,GAO P,CHENG J Q,et al.Enhancing anaerobic digestion and methane production of tetracycline wastewater in EGSB reactor with GAC/NZVI mediator[J].Water Research,2018,136:54.
[42] LI C X,WANG R M,YANG X Y,et al.Deeper investigation on methane generation from synthetic wastewater containing oxytetracycline in a scale up acidic anaerobic baffled reactor[J].Bioresource Technology,2021,333:125156.
[43] LU M Q,NIU X J,LIU W,et al.Biogas generation in anaerobic wastewater treatment under tetracycline antibiotic pressure[J].Scientific Reports,2016,6:28336.
[44] QIU G L,SONG Y H,ZENG P,et al.Combination of upflow anaerobic sludge blanket (UASB) and membrane bioreactor (MBR) for berberine reduction from wastewater and the effects of berberine on bacterial community dynamics[J].Journal of Hazardous Materials,2013,246-247:34.
[45] WEI M Q,ZHANG R N,ZHOU M J,et al.Treatment of fresh leachate by microaeration pretreatment combined with IC-AO2 process:performance and mechanistic insight[J].Science of the Total Environment,2021,789:147939.
[46] ZHU T,SU Z,LAI W,et al.Evaluating the impact of sulfamethoxazole on hydrogen production during dark anaerobic sludge fermentation[J].Frontiers of Environmental Science & Engineering,2022,17(1).
[47] FENG L Y,YUAN F Y,XIE J,et al.Sulfadiazine inhibits hydrogen production during sludge anaerobic fermentation by affecting pyruvate decarboxylation[J].Science of the Total Environment,2022,838(Pt 4):156415.
[48] CHEN H B,ZENG X N,ZHOU Y Y,et al.Influence of roxithromycin as antibiotic residue on volatile fatty acids recovery in anaerobic fermentation of waste activated sludge[J].Journal of Hazardous Materials,2020,394:122570.
[49] HUANG W W,YANG F,HUANG W L,et al.Enhancing hydrogenotrophic activities by zero-valent iron addition as an effective method to improve sulfadiazine removal during anaerobic digestion of swine manure[J].Bioresource Technology,2019,294:122178.
[50] ZOU H,CAI Y,LI J,et al.The impact mechanism of chlortetracycline on different stages of anaerobic fermentation of organic wastes[J].Journal of Environmental Chemical Engineering,2022,10(3).
[51] YANG G,WANG J L.Enhanced antibiotic degradation and hydrogen production of deacetoxycephalosporin C fermentation residue by gamma radiation coupled with nano zero-valent iron[J].Journal of Hazardous Materials,2022,424(Pt B):127439.
[52] HE D,XIAO J,WANG D,et al.Understanding and regulating the impact of tetracycline to the anaerobic fermentation of waste activated sludge[J].Journal of Cleaner Production,2021,313.
[53] LIU Z G,SUN P Z,PAVLOSTATHIS S G,et al.Inhibitory effects and biotransformation potential of ciprofloxacin under anoxic/anaerobic conditions[J].Bioresource Technology,2013,150:28.
[54] WANG Y,HE Y Y,LI X Q,et al.Enhanced biodegradation of chlortetracycline via a microalgae-bacteria consortium[J].Bio-resource Technology,2022,343.
[55] PARANHOS A G O,PEREIRA A R,DA FONSECA Y A,et al.Tylosin in anaerobic reactors:degradation kinetics,effects on methane production and on the microbial community[J].Biodegradation,2022,33(3):283.
[56] áLVAREZ J A,OTERO L,LEMA J M,et al.The effect and fate of antibiotics during the anaerobic digestion of pig manure[J].Bioresource Technology,2010,101(22):8581.
[57] ZHAO R X,FENG J,LIU J,et al.Deciphering of microbial community and antibiotic resistance genes in activated sludge reactors under high selective pressure of different antibiotics[J].Water Research,2019,151:388.
[58] TAMMINEN M,KARKMAN A,LOHMUS A,et al.Tetracycline resistance genes persist at aquaculture farms in the absence of selection pressure[J].Environmental Science & Technology,2011,45(2):386.
[59] GAO P P,MAO D Q,LUO Y,et al.Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment[J].Water Research,2012,46(7):2355.
[60] LIN Z B,YUAN T,ZHOU L,et al.Impact factors of the accumulation,migration and spread of antibiotic resistance in the environment[J].Environmental Geochemistry and Health,2021,43(5):1741.
[61] AZIZ A,SENGAR A,BASHEER F,et al.Anaerobic digestion in the elimination of antibiotics and antibiotic-resistant genes from the environment-A comprehensive review[J].Journal of Environmental Chemical Engineering,2022,10(1).
[62] ZHU T T,SU Z X,LAI W X,et al.Insights into the fate and removal of antibiotics and antibiotic resistance genes using biological wastewater treatment technology[J].Science of the Total Environment,2021,776.
[63] MA Y J,WILSON C A,NOVAK J T,et al.Effect of various sludge digestion conditions on sulfonamide,macrolide,and tetracycline resistance genes and class I integrons[J].Environmental Science & Technology,2011,45(18):7855.
[64] CHENG X S,ZHANG L,WEI Z C,et al.Distinct effects of typical sludge pretreatment approaches on the antibiotic resistance genes variations,associated bacterial community dynamics and metabolic activities during anaerobic fermentation process[J].Environmental Research,2023,216(Pt 4):114767.
[65] RAZA S,KANG K H,SHIN J,et al.Variations in antibiotic resistance genes and microbial community in sludges passing through biological nutrient removal and anaerobic digestion processes in municipal wastewater treatment plants[J].Chemosphere,2023,313:137362.
[66] CHENG D L,NGO H H,GUO W S,et al.A critical review on antibiotics and hormones in swine wastewater:Water pollution problems and control approaches[J].Journal of Hazardous Materials,2020,387:121682.
[67] SUN W,GU J,WANG X,et al.Impacts of biochar on the environmental risk of antibiotic resistance genes and mobile genetic elements during anaerobic digestion of cattle farm wastewater[J].Bioresource Technology,2018,256:342.
[68] STANGE C,SIDHU J P S,TOZE S,et al.Comparative removal of antibiotic resistance genes during chlorination,ozonation,and UV treatment[J].International Journal of Hygiene and Environmental Health,2019,222(3):541.
[69] AHMED Y,LU J,YUAN Z,et al.Efficient inactivation of antibiotic resistant bacteria and antibiotic resistance genes by photo-Fenton process under visible LED light and neutral pH[J].Water Research,2020,179.
[70] ZHANG J Y,SUI Q W,ZHONG H,et al.Impacts of zero valent iron,natural zeolite and dnase on the fate of antibiotic resistance genes during thermophilic and mesophilic anaerobic digestion of swine manure[J].Bioresource Technology,2018,258:135.
[71] SUN W,QIAN X,GU J,et al.Mechanism and effect of temperature on variations in antibiotic resistance genes during anaerobic digestion of dairy manure[J].Scientific Reports,2016,6:30237.
[72] TIAN Z,ZHANG Y,YU B,et al.Changes of resistome,mobilome and potential hosts of antibiotic resistance genes during the transformation of anaerobic digestion from mesophilic to thermo-philic[J].Water Research,2016,98:261.
[73] LI M M,RAY P,TEETS C,et al.Increasing temperature and pH can facilitate reductions of cephapirin and antibiotic resistance genes in dairy manure slurries[J].Journal of Dairy Science,2020,103(3):2877.
[74] HUANG H N,CHEN Y G,ZHENG X,et al.Distribution of tetracycline resistance genes in anaerobic treatment of waste sludge:the role of pH in regulating tetracycline resistant bacteria and horizontal gene transfer[J].Bioresource Technology,2016,218:1284.
[75] YU P,DONG P,ZOU Y,et al.Effect of pH on the mitigation of extracellular/intracellular antibiotic resistance genes and antibiotic resistance pathogenic bacteria during anaerobic fermentation of swine manure[J].Bioresource Technology,2023,373:128706.
