2026年 03期

摘要(Abstract)：

针对酶驱纳米马达在作为活性递送载体时因生理底物浓度较低而导致驱动力不足的问题，利用配体竞争性吸附诱导二氧化硅SiO₂在金Au纳米粒子表面非对称生长，制备双面神结构的Au-SiO₂纳米粒子，并以其为载体，通过固定过氧化氢酶和脲酶，制备以过氧化氢H₂O₂和尿素为燃料的纳米马达，研究过氧化氢酶与脲酶的负载比例对模拟生理环境中纳米马达运动性能的影响。结果表明：表面修饰过氧化氢酶和脲酶制备的Au-SiO₂纳米马达在H₂O₂、尿素浓度不同的模拟生理环境中表现出显著优于单酶负载纳米马达的运动性能；当过氧化氢酶与脲酶的物质的量比为1∶3时，纳米马达的运动性能最佳；纳米马达的扩散系数与底物浓度的依赖关系表明该纳米马达对尿素的响应要优于对H₂O₂的响应。

关键词(KeyWords)：纳米马达;双面神结构;过氧化氢酶;脲酶;运动性能

基金项目(Foundation):国家重点研发计划项目(2021YFA1201400)

作者(Author):曹晶晶,许蕾蕾

DOI:10.13349/j.cnki.jdxbn.20260316.002

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